Infectoforum

CONCLUSIONS: In this study, there was significant overexpression of mazE6 in drug-susceptible isolates. As well, mazF3 and F6 were overexpressed in drug-resistant isolates when compared with the standard strain. The changes in expression levels of MazEF6 associated genes were greater than that of MazEF3 in both groups of isolates.

CONCLUSION: Burkholderia contaminans SBC01 belonging to sequence type ST482 is a multi-drug resistant strain containing diverse resistance genes revealing the risks associated with infections of new Burkholderia spp. The large G+C rich genome has myriad of virulence factors highlighting its pathogenic potential. Thus, while providing insights into AMR and virulence potential of this uncommon species, the present analysis will aid in understanding the evolution and speciation in Burkholderia…

The high expression of multidrug resistance-associated protein 1 (MRP1) in cancer cells caused serious multidrug resistance (MDR), which limited the effectiveness of paclitaxel (PTX) in non-small cell lung cancer (NSCLC) chemotherapy. Indomethacin (IND), a kind of non-steroidal anti-inflammatory drugs (NSAIDs), which has been confirmed to be a potential MRP1 inhibitor. Taking into account the advantages of old drugs without extra controversial biosafety issue, in this manuscript, the disulfide…

CONCLUSION: Considering the selection pressure exerted by the extensive use of ceftriaxone in India, there are potential risks for the occurrence of plasmid transmission events in the predominant H58 lineages. Therefore, continuous monitoring of S. Typhi lineages carrying plasmid-mediated cephalosporin resistant genes is vital not just for India but also globally.

CONCLUSION: Between 2014 and 2018, the incidence of RR-TB increased especially among newly-diagnosed TB patients. We recommend intensified efforts and screening for early diagnosis especially among previously treated patients. Mechanisms should be in put to ensure that all patients with RR-TB obtain DST.

Antimicrobial peptides (AMPs) have now been extensively studied to combat or control bacterial and fungal pathogens. However, AMPs oral administration can be challenging due to physicochemical instability during their gastrointestinal transport. Also, uncontrolled application could generate unwanted hemolytic activity. Microencapsulation is a potential biotechnological tool, which can overcome antimicrobial peptides (AMP) instabilities and reduce toxic side effects. Thus, this study evaluates…

The main role of platelets is to contribute to hemostasis. However, under pathophysiological conditions, platelet activation may lead to thrombotic events of cardiovascular diseases. Thus, anti-thrombotic treatment is important in patients with cardiovascular disease. This review focuses on a platelet receptor, a transmembrane protein, the Multidrug Resistance Protein 4, MRP4, which contributes to platelet activation by extruding endogenous molecules responsible for their activation and…

Liver abscess is a rare condition, associated with significant in-hospital mortality. Due to improved diagnostic yield and standardized treatment strategies, mortality has been reduced from 70% to 6% in the last decades.