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junio 3, 2020

In Vitro Activity of the Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales (CRE) With Varying Intrinsic and Acquired Resistance Mechanisms

QPX7728 is an investigational ultra-broad-spectrum beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in isogenic strains of gram-negative bacteria producing various beta-lactamases. The potency of meropenem alone and in combination with QPX7728 (tested at fixed 1-16 μg/ml) was tested against 598 clinical isolates of carbapenem-resistant Enterobacterales. The panel included 363…