Healthcare-associated infections are a serious problem worldwide, as they increase morbidity, mortality and lengthen hospital stays. About 10-20% of patients on mechanical ventilation risk developing ventilator-associated pneumonia (VAP), which varies by geographical region but still is the second most common nosocomial infection in the paediatric intensive care unit (PICU). VAP mortality is up to 20% in paediatrics.
Prolonged infusion of linezolid is associated with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles in patients with external ventricular drains.
Eur J Clin Pharmacol. 2020 Aug 18;:
Predictive Modeling of Bacterial Infections and Antibiotic Therapy Needs in Critically Ill Adults.
J Biomed Inform. 2020 Aug 16;:103540
Authors: Eickelberg G, Nelson Sanchez-Pinto L, Luo Y