CONCLUSIONS: LUPPIS appears to provide better results in the prediction of VAP compared to CPIS, and the importance of lung ultrasound and PTX-3 is emphasized, which is a distinctive property of LUPPIS.
National Trends in Oral Antibiotic Prescribing in United States Physician Offices from 2009 to 2016.
Pharmacotherapy. 2020 Aug 31;:
Authors: Young EH, Panchal RM, Yap AG, Reveles KR
Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses.
PLoS Negl Trop Dis. 2020 Aug 31;14(8):e0007857
Authors: Chauffour A, …
High degree of fluoroquinolone resistance among extrapulmonary tuberculosis patients at a tertiary care center in North India.
Int J Mycobacteriol. 2020 Jul-Sep;9(3):309-312
Authors: Chaubey J, Shri…
Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells.
Med Sci Monit. 2020 Aug 30;26:e924435
Authors: Ma Y, Wen J, Wang J, Wang C, Zhang…
In vivo pharmacodynamics of new-generation β-lactamase inhibitor taniborbactam (formerly VNRX-5133) in combination with cefepime against serine-β-lactamase-producing Gram-negative bacteria.
J Antimicrob Chem…
Liaison of Sugar Control With Time to Sputum Culture Conversion in Multi-Drug Resistant Tuberculosis.
Cureus. 2020 Jul 26;12(7):e9395
Authors: Jafri S, Ahmed N, Saifullah N, Jawad N, Siddiqui IA
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ulcerans using a BU animal model. The imidazopyridine amine telacebec (Q203) exhibited high bactericidal activity whereas tedizolid (an oxazolidinone closely related to linezolid),…
CONCLUSIONS: In our in vitro system, post-distributional dalbavancin exposures selected for stable mutants with reduced susceptibility to dalbavancin, vancomycin, and daptomycin, and generally increased susceptibility to β-lactams in all strains of MRSA tested. The clinical significance of these findings remains unclear, but created an opportunity to genotype a unique collection of dalbavancin-resistant strains for the first time. Mutations involved genes previously associated with vancomycin…