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septiembre 9, 2020

DNA Encapsidation and Capsid Assembly Are Underexploited Antiviral Targets for the Treatment of Herpesviruses

Although there are effective nucleoside analogs to treat HSV, VZV, and HCMV disease, herpesvirus infections continue to contribute to significant morbidity and mortality. Acyclovir is the drug of choice for HSV encephalopathy, yet there is an estimated 6-19% mortality rate with half of the survivors experiencing moderate to severe chronic neurological deficits. For VZV, current treatments are inadequate to prevent acute and persistent pain due to zoster. Treatment of HCMV with GCV requires close…

Advances in Neonatal Infections.

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Advances in Neonatal Infections.
Am J Perinatol. 2020 Sep;37(S 02):S5-S9
Authors: Fanaroff AA, Fanaroff JM
Abstract
Despite continued advances and developments in neonatal medicine, …