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noviembre 13, 2020

New β-Lactam-β-Lactamase Inhibitor Combinations.

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New β-Lactam-β-Lactamase Inhibitor Combinations.
Clin Microbiol Rev. 2020 Dec 16;34(1):
Authors: Yahav D, Giske CG, Grāmatniece A, Abodakpi H, Tam VH, Leibovici L

Structural Basis for the Binding Mechanism of Human Serum Albumin Complexed with Cyclic Peptide Dalbavancin

Cyclic peptides, with unique structural features, have emerged as new candidates for drug discovery; their association with human serum albumin (HSA; long blood half-life) is crucial to improve drug delivery and avoid renal clearance. Here, we present the crystal structure of HSA complexed with dalbavancin, a clinically used cyclic peptide. Small-angle X-ray scattering and isothermal titration calorimetry experiments showed that the HSA-dalbavancin complex exists in a monomeric state;…

Invasive pulmonary aspergillosis associated with COVID-19 in a kidney transplant recipient

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might increase the risk of invasive pulmonary aspergillosis (IPA). Although several case reports and small series have been reported in the general population, scarce information is available regarding coronavirus disease 2019 (COVID-19)-associated IPA in the setting of solid organ transplantation. We describe a case of a kidney transplant recipient with severe COVID-19 that was subsequently diagnosed with probable IPA on the basis of…