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noviembre 28, 2020

Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia

Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic pleuromutilin with a chemical structure that contains a tricyclic core of five-, six-, and eight-membered rings and a 2-(4-amino-2-hydroxycyclohexyl)sulfanylacetate side chain extending from C14 of the tricyclic core. Lefamulin inhibits bacterial protein synthesis by binding to the 50S bacterial ribosomal subunit in the…

Current Status of Vancomycin Analytical Methods.

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Current Status of Vancomycin Analytical Methods.
J AOAC Int. 2020 Jun 01;103(3):755-769
Authors: Do Nascimento PA, Kogawa AC, Salgado HRN
Abstract
BACKGROUND: The glycopeptide antib…