Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic pleuromutilin with a chemical structure that contains a tricyclic core of five-, six-, and eight-membered rings and a 2-(4-amino-2-hydroxycyclohexyl)sulfanylacetate side chain extending from C14 of the tricyclic core. Lefamulin inhibits bacterial protein synthesis by binding to the 50S bacterial ribosomal subunit in the…
Metallotherapeutics development in the age of iron-clad bacteria.
Metallomics. 2020 Nov 26;:
Authors: Centola G, Xue F, Wilks A
Drug-resistant infections pose a significant…
Aspirin or verapamil increased the sensitivity of Candida albicans to caspofungin under planktonic and biofilm conditions.
J Glob Antimicrob Resist. 2020 Nov 23;:
Authors: Feng W, Yang J, Ma Y, Xi …
The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection.
Comput Struct Biotechnol J. 2020;18:3324-3334
Authors: Nguyen HTT, Nguyen TH, Ott…
The microcolony detection method (MCD), a simple and rapid screening test for antimicrobial resistance bacteria on positive blood cultures.
Heliyon. 2020 Nov;6(11):e05494
Authors: Kuchibiro T, Hir…
Current Status of Vancomycin Analytical Methods.
J AOAC Int. 2020 Jun 01;103(3):755-769
Authors: Do Nascimento PA, Kogawa AC, Salgado HRN
BACKGROUND: The glycopeptide antib…
Modelling how antimicrobial resistance spreads between wards.
Elife. 2020 Nov 26;9:
Authors: Donker T
Moving patients between wards and prescribing high levels of antibioti…
Secondary osteomyelitis from contiguous intrapelvic hematoma.
Pediatr Int. 2020 Nov;62(11):1301-1303
Authors: Muraki K, Kusama Y, Takeuchi N, Ishiwada N
PMID: 33242921 [PubMed – as supplied…
WHAT IS KNOWN AND OBJECTIVE: Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration.