Invasive fungal infections (IFIs) are associated with high mortality rates and timely appropriate antifungal therapy is essential for good outcomes. Emerging antifungal resistance among Candida and Aspergillus spp., the major causes of IFI, is concerning and has led to the increasing incorporation of in vitro antifungal susceptibility testing (AST) to guide clinical decisions. However, the interpretation of AST results and their contribution to management of IFIs remains a matter of debate….
Gastrointestinal colonization by Candida species is considered the main source of candidemia. The ERG3 gene in Candida albicans encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis. Although ERG3 inactivation shows reduced virulence in mouse models of disseminated candidiasis, the role of ERG3 in intestinal infections is unknown. Here, we infected mice with the C. albicans strains CAE3DU3 and CAF2-1, containing mutant and wild-type ERG3, respectively, and studied gut…
This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides like the polymyxins as well as peptides addressing targets located in the plasma membrane or in the outer membrane of bacterial cells are discussed.
Lymphocele Containing Staphylococcus lugdunensis.
Cureus. 2020 Nov 23;12(11):e11666
Authors: Keerty D, Das M, Hembree TN, Ramsakal A, Haynes E
Staphylococcus species are a l…
CONCLUSIONS: The posaconazole PBPK models were developed and clinically verified. Predictions using the robust PBPK model confirmed the venetoclax label recommendation of 70 mg in the presence of posaconazole at doses up to 500 mg QD.
CONCLUSIONS: The proposed protocol can provide reliable bacterial identification and data concerning β-lactam resistance in only 3 hours, positively improving management of patients in terms of antimicrobial stewardship.
Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus-Induced Infection in Rats.
Biol Trace Elem Res. …
Prevalence of Enterobacteriaceae spp. and its multidrug-resistant rates in clinical isolates: A two-center cross-sectional study.
Mol Biol Rep. 2021 Jan 03;:
Authors: Mirzaei B, Babaei R, Bazgir ZN…
Insight on Multidrug Resistance and Nanomedicine Approaches to Overcome MDR.
Crit Rev Ther Drug Carrier Syst. 2020;37(5):473-509
Authors: Mohammad IS, He W, Yin L
Colorectal Cancer Biology, Diagnosis, and Therapeutic Approaches.
Crit Rev Oncog. 2020;25(2):71-94
Authors: Dariya B, Aliya S, Merchant N, Alam A, Nagaraju GP