enero 12, 2021

CONCLUSION: COVID-19 is associated with an increased risk of VAP, which is not fully explained by the prolonged duration of ventilation. The pulmonary dysbiosis caused by COVID-19, and the causative organisms of secondary pneumonia observed are similar to that seen in critically ill patients ventilated for other reasons.

CONCLUSIONS: The present review assesses related studies regarding the therapeutic effect of VPXETS on preventing VAP at ICUs.

CONCLUSIONS: Long-term use of tedizolid was effective, showing a better safety profile with less myelotoxicity and lower drug-drug interaction than linezolid. Confirmation of these advantages could make tedizolid the oxazolidinone of choice for most of osteoarticular infections.

The emergence of Gram-negative resistance during antibacterial therapy yields worse clinical outcomes and increased antimicrobial resistance worldwide. We evaluated the emergence of nonsusceptibility to ceftolozane/tazobactam and meropenem among participants with Pseudomonas aeruginosa lower respiratory tract isolates from ASPECT-NP, a phase 3, randomized, double-blind, multicenter study that demonstrated the noninferiority of a ceftolozane/tazobactam 3-g dose q8h versus a meropenem 1-g dose q8h…

A total of 15 Candida auris isolates from the SENTRY Antimicrobial Surveillance Program between 2006 and 2019 were combined with 21 isolates from other collections for the evaluation of antifungal susceptibility and synergy against anidulafungin plus voriconazole or isavuconazole using the checkerboard method. Surveillance isolates were analyzed for genetic relatedness and resistance mechanisms. Applying the tentative statistical epidemiological cutoff values and the Centers for Disease Control…