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enero 26, 2021

Comparative pharmacodynamics of echinocandins against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model that correlates with clinical response to caspofungin therapy: Is there a place for dose optimization?

Background. Echinocandins have been used as primary therapy of invasive aspergillosis (IA) with sub-optimal results at standard dosing. We explored the efficacy of dose escalation in a validated in vitro PK/PD modelMethods. Six echinocandin WT and three non-WT A. fumigatus isolates were tested in the in vitro PK/PD model simulating anidulafungin, caspofungin and micafungin exposures with fC(max) 0.01-16 mg/L and t(1/2)=8-22h. The relationship between the fAUC(0-24)/MEC and % aberrant mycelia…

Ceftolozane/Tazobactam-Induced Leukocytosis and Clinical Failure in a Patient Being Treated for Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Pseudomonas aeruginosa: a Case Report

Ceftolozane/tazobactam is an intravenous beta-lactam/beta-lactamase inhibitor that utilizes a novel oxyimino-cephalosporin with a traditional beta-lactamase inhibitor. It is approved by the Food and Drug Administration to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and, most recently, hospital-acquired bacterial and ventilator-associated bacterial pneumonias. It is commonly utilized to treat infections caused by…