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febrero 9, 2021

The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry?

The World Health Organization (WHO) considers mycetoma, chromoblastomycosis, and paracoccidioidomycosis to be fungal neglected tropical diseases (FNTDs). Depending on climatic, cultural, and economic contexts, these diseases have a similar geographical distribution as many other diseases, particularly tuberculosis (TB) and malaria, but are often less targeted by the national and many international healthcare systems. Another subgroup of fungal infections, such as candidiasis, cryptococcosis,…

LFchimera: a synthetic mimic of the two antimicrobial domains of bovine lactoferrin

Saliva is essential for the maintenance of oral health. When salivary flow is impaired, the risk of various oral diseases such as caries and candidiasis increases drastically. Under healthy conditions, saliva provides effective protection against microbial colonization by the collaborative action of numerous host-defense molecules. This review describes how saliva has been the guideline for the design and characterization of a heterodimeric antimicrobial construct called LFchimera. This…

High-dose micafungin in neonates and young infants with invasive candidiasis: results of a phase 2 study

Limited data are available on the most appropriate dosing, efficacy and safety of micafungin in neonates with invasive candidiasis (IC). This study evaluated plasma levels, efficacy and safety of micafungin at a dose of 8 mg/kg/day for a mean of 13·3 (± 5·2) days in 35 neonates and young infants with IC. Micafungin plasma concentrations were 5·70 mg/L pre-administration and 17·23, 15·59 and 10·27 mg/L after 1, 2, and 8 hours, respectively. The resolution of the infection was achieved in 86·7% of…

Respiratory microbiome in mechanically ventilated patients: a narrative review

The respiratory microbiome has been less explored than the gut microbiome. Despite the speculated importance of dysbiosis of the microbiome in ventilator-associated pneumonia (VAP) and acute respiratory distress syndrome (ARDS), only few studies have been performed in invasively ventilated ICU patients. And only the results of small cohorts have been published. An overlap exists between bacterial populations observed in the lower respiratory tract and the oropharyngeal tract. The bacterial…

Nouveau short-course therapy and morphism mapping for clinical pulmonary <em>Mycobacterium kansasii</em>

Standard therapy [isoniazid, rifampin, ethambutol], with or without a macrolide, for pulmonary Mycobacterium kansasii lasts more than a year. Therefore, shorter treatment duration regimens are required. We used data from 32 Taiwanese patients treated with standard therapy who were followed using repetitive sampling-based sputum Mkn time-to-positivity in liquid cultures to calculate kill slopes [γ] based on ordinary differential equations and time-to-extinction of each patient’s bacterial burden….