Invasive fungal disease (IFD) can be a severe treatment complication in patients with myeloid malignancies, but current risk models do not incorporate disease-specific factors, such as somatic gene mutations. Germline GATA2 deficiency is associated with a susceptibility to IFD. To determine whether myeloid gene mutations were associated with IFD risk, we identified 2 complementary cohorts of patients with myeloid malignancy, based on (1) the diagnosis of invasive aspergillosis (IA), or (2) the…
Candida parapsilosis has emerged as a frequent cause of invasive candidiasis with increasing evidence of unique biological features relative to C. albicans As it adapts to conditions within a mammalian host, rapid changes in gene expression are necessary to facilitate colonization and persistence in this environment. Adhesion of the organism to biological surfaces is a key first step in this process and is the focus of this study. Building on previous observations showing the importance of a…
Three new coinage metal carbene complexes of silver and gold were synthesized from a thiamine inspired proligand. The compounds were characterized by HRMS, NMR spectroscopy (¹H, ^(19)F, ^(31)P and ^(13)C), FT-IR and elemental analysis. The coordination environment around the metal centers was correlated to the diffusion coefficients obtained from DOSY-NMR experiments and was in agreement with the nuclearity observed in the solid-state by single crystal X-ray crystallography. The silver and gold…
Letter on «(1,3)-β-D-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial».
Crit Care. 2021 02 09;25(1):55
Authors: Kritikos A, Lamoth F
Disseminated Nocardiosis in a Renal Transplant Recipient.
Cureus. 2021 Jan 05;13(1):e12497
Authors: Ghandour M, Shereef H, Homida H, Revankar S, Zachariah MS
Ocular pathogens and antibiotic resistance in microbial keratitis over three years in Harbin, Northeast China.
Acta Ophthalmol. 2021 Feb 10;:
Authors: Xu S, Guo D, Liu X, Jin X, Shi Y, Wang Y, Zhan…
From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics.
Clin Pharmacol Ther. 2021 Feb 10;:
Authors: Wicha SG, Märtson AG, Nielsen EI, Koch BCP, Friberg LE, Alffenaar JW…
[Lung disease by Mycobacterium chelonae in an immunocompetent patient successfully treated with linezolid].
Rev Peru Med Exp Salud Publica. 2020 Oct-Dec;37(4):785-787
Authors: Pecho-Silva S, Navarro…
Species diversity and antibiotic resistance of Staphylococci isolated in children of the first month of life in children’s hospitals in Nizhny Novgorod.
Klin Lab Diagn. 2021 Feb 10;66(1):42-44
CONCLUSIONS: Mucormycosis is associated with a high mortality rate in patients with HM, especially in allogeneic SCT recipients. Benefit of ICU management in these patients should be assessed before admission and strategies aiming to improve these patients’ outcome are urgently needed.