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febrero 16, 2021

Staphylococcus aureus Colonisation in HIV-Infected Patients: Incidence, Risk Factors and Subsequent Skin- and Soft-Tissue Infections

We evaluated the incidence and risk factors of Staphylococcus aureus colonisation in 300 treatment-naïve HIV patients. Swabs from anterior nares and pharynx were cultured. Eighty-eight patients (29.3%) were colonised with S. aureus (47.7% nasal, 23.8% pharyngeal and 28.5% at both sites), which yielded 112 isolates. Methicillin-resistant S. aureus was detected in 25.9% (29/112) of isolates. Panton-Valentine leucocidin gene was present in 18.8% (21/112) of isolates. Multiple logistic regression…

Prevalence of Oxacillin-Susceptible Methicillin-Resistant Staphylococcus aureus Nasal Carriage and their Clonal Diversity among Patients Attending Public Health-Care Facilities

CONCLUSIONS: There is a gradual colonisation shift happening in the infection pattern by S. aureus in Brazil. The Brazilian Epidemic Clone (ST239-SCCmecIIIa-PVL-) seems to be substituted by isolates from different clonal complexes, such as ST5, ST8 and ST30. The non-correlation between phenotypic/genotypic resistance profile observed in some isolates suggests the presence of other methicillin resistance mechanisms different from mecA presence or a difference in the nucleotide sequence, which…

A Comparative Assessment of Clinical, Pharmacological and Antimicrobial Profile of Novel Anti-methicillin-resistant Staphylococcus aureus Agent Levonadifloxacin: Therapeutic Role in Nosocomial and Community Infections

Staphylococcus aureus is of significant clinical concern in both community- and hospital-onset infections. The key to the success of S. aureus as a pathogen is its ability to swiftly develop antimicrobial resistance. Methicillin-resistant S. aureus (MRSA) is not only resistant to nearly all beta-lactams but also demonstrates resistance to several classes of antibiotics. A high prevalence of MRSA is seen across worldwide. For many decades, vancomycin remained as gold standard antibiotic for the…