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febrero 19, 2021

Review of Fluconazole Treatment and Prophylaxis for Invasive Candidiasis in Neonates

Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of America provides guidelines on antifungal medications for the prophylaxis and treatment of candidiasis in NICUs; however, there are still variations…

CuO(1-x)ZnOx Nanocomposite with Broad Spectrum Antibacterial Activity: Application In Medical Devices and Acrylic Paints

Inappropriate and disproportionate use of antibiotics have led to a rapid increase in antibacterial resistance. Therefore, alternative antibacterial strategies and solutions are sought to overcome any form of resistance to effectively treat and/or prevent the spread of infections. In this study, we report an eco-friendly and scalable approach to produce highly antibacterial CuO(1-x)ZnOx nanocomposite and its inclusion in medical devices and acrylic paint. Nanocomposite has nanoporous structure…

A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in…

The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides

The X family is one of the eight families of DNA polymerases (dPols) and members of this family are known to participate in the later stages of Base Excision Repair. Many prokaryotic members of this family possess a Polymerase and Histidinol Phosphatase (PHP) domain at their C-termini. The PHP domain has been shown to possess 3′-5′ exonuclease activity and may represent the proofreading function in these dPols. PolX from Staphylococcus aureus also possesses the PHP domain at the C-terminus, and…

Early tracheostomy in stroke patients: A meta-analysis and comparison with late tracheostomy

Tracheostomy (TQT) timing and its benefits is a current discussion in medical society. We aimed to compare the outcomes of early (ET) versus late tracheostomy (LT) in stroke patients with systematic review and meta-analysis, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Five hundred and nineteen studies were retrieved, whereas three were selected for the systematic review and meta-analysis. There were 5636 patients in the ET group (3151 male,…