Currently browsing

febrero 26, 2021

Potent intracellular antibacterial activity of a marine peptide-N6NH<sub>2</sub> and its D-enantiomer against multidrug-resistant Aeromonas veronii

Aeromonas veronii can cause a variety of diseases such as sepsis in humans and animals. However, there has been no effective way to eradicate A. veronii. In this study, the intracellular antibacterial activities of the C-terminal aminated marine peptide N6 (N6NH(2)) and its D-enantiomer (DN6NH(2)) against A. veronii were investigated in macrophages and in mice, respectively. The result showed that DN6NH(2) with the minimum inhibitory concentration (MIC) of 1.62 μM is more resistant to cathepsin…

Candida albicans CHK1 gene from two-component system is essential for its pathogenicity in oral candidiasis

The roles of Candida albicans CHK1, a key gene from two-component system, in oral mucosal infection are not clear. This study evaluated the key roles of CHK1 gene in vitro and in vivo. The expression of CHK1 and its regulated virulence factors were tested during the oral epithelial cell infection. The production of lactate dehydrogenase, ROS, and IL-1α combined with the confocal and scanning electron microscope observation was employed to identify the capability of CHK1 in damaging the…

<em>Phialemoniopsis limonesiae</em> sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman

Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding a sero-purulent discharge. A filamentous fungus was isolated from pus and cutaneous biopsy. ITS and LSU sequences phylogenetically resolved…