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abril 26, 2021

The Length of Tibialis Anterior Does Not Influence Force Steadiness During Submaximal Isometric Contractions with the Dorsiflexors

The purpose of the study was to assess the influence of short, intermediate, and long muscle lengths on dorsiflexor force steadiness and the discharge characteristics of motor units in tibialis anterior during submaximal isometric contractions. Steady contractions were performed at 5 target forces (5, 10, 20, 40, and 60% maximal voluntary contraction, MVC) for 3 ankle angles (75^(ο), 90^(ο), and 105^(o)). MVC force was less (p=0.043) at the smallest joint angle compared with the other two…

Safety profile of carbapenems: Data mining of the FDA adverse events reporting system

CONCLUSION: Carbapenem resistance is alarming in the United States, and carbapenem is more likely to be associated with serious and fatal ADEs among β-lactam antibiotics. Both differences and similarities exist in the safety profile among carbapenems classes. Close attention should be paid to patients with special disease when administrated carbapenems.

Disbalancing Envelope Stress Responses as a Strategy for Sensitization of <em>Escherichia coli</em> to Antimicrobial Agents

Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial agents. Seventeen isogenic strains were selected from the KEIO collection with deletions in genes corresponding to the σ^(E), Cpx, Rcs, Bae, and Psp responses. Antimicrobial activity against 20 drugs with different targets was evaluated by disk diffusion and gradient strip tests. Growth curves and time-kill curves were also determined for selected mutant-antimicrobial…

Clinical descriptive analysis of severe <em>Pneumocystis jirovecii</em> pneumonia in renal transplantation recipients

Pneumocystis jirovecii (P. jirovecii) pneumonia (PJP) is an opportunistic fungal infection after renal transplantation, which is always severe, difficult to diagnose, combined with multiple complications and have poor prognosis. We retrospectively analyzed clinical data, including risk factors, diagnosis, treatment and complications of seven clinical cases suffered with severe PJP after renal transplantation in our department in 2019. All the seven recipients were routinely prescribed with PJP…

Antifungal agents and the kidney: pharmacokinetics, clinical nephrotoxicity, and interactions

INTRODUCTION: Invasive fungal infections continue to be important causes of morbidity and mortality in severely ill and immunocompromised patient populations. The past three decades saw a considerable expansion in antifungal drug research, resulting in the clinical development of different classes of antifungal agents with different pharmacologic properties. Among drug-specific characteristics of antifungal agents, renal disposition and nephrotoxicity are important clinical considerations as…