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mayo 9, 2021

Guidelines for Infection Prophylaxis, Monitoring and Therapy in Cord Blood Transplantation

As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include…

Antimicrobial resistance in bacterial isolates from companion animals in Buenos Aires, Argentina: 2011-2017 retrospective study

The widespread use of antimicrobial therapy in companion animals could lead to increased levels of resistance. Monitoring these levels is critical to understand not only the zoonotic threat of resistant bacteria but also the interspecies transmission of resistance mechanisms. However, data on resistance levels in companion animals of urban areas in Latin America are lacking. In this retrospective study, we analysed 23,922 isolates recovered from clinical samples of dogs and cats between 2011 and…

Genomic and phylogenetic analysis of a multi drug resistant Burkholderia contaminans strain isolated from a patient with ocular infection

CONCLUSION: Burkholderia contaminans SBC01 belonging to sequence type ST482 is a multi-drug resistant strain containing diverse resistance genes revealing the risks associated with infections of new Burkholderia spp. The large G+C rich genome has myriad of virulence factors highlighting its pathogenic potential. Thus, while providing insights into AMR and virulence potential of this uncommon species, the present analysis will aid in understanding the evolution and speciation in Burkholderia…

Van der Waals force-driven indomethacin-ss-paclitaxel nanodrugs for reversing multidrug resistance and enhancing NSCLC therapy

The high expression of multidrug resistance-associated protein 1 (MRP1) in cancer cells caused serious multidrug resistance (MDR), which limited the effectiveness of paclitaxel (PTX) in non-small cell lung cancer (NSCLC) chemotherapy. Indomethacin (IND), a kind of non-steroidal anti-inflammatory drugs (NSAIDs), which has been confirmed to be a potential MRP1 inhibitor. Taking into account the advantages of old drugs without extra controversial biosafety issue, in this manuscript, the disulfide…

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile<sup>21</sup>)-Ha antimicrobial peptide application as a feed additive

Antimicrobial peptides (AMPs) have now been extensively studied to combat or control bacterial and fungal pathogens. However, AMPs oral administration can be challenging due to physicochemical instability during their gastrointestinal transport. Also, uncontrolled application could generate unwanted hemolytic activity. Microencapsulation is a potential biotechnological tool, which can overcome antimicrobial peptides (AMP) instabilities and reduce toxic side effects. Thus, this study evaluates…

Multidrug Resistance Protein 4 (MRP4/ABCC4): A Suspected Efflux Transporter for Human’s Platelet Activation

The main role of platelets is to contribute to hemostasis. However, under pathophysiological conditions, platelet activation may lead to thrombotic events of cardiovascular diseases. Thus, anti-thrombotic treatment is important in patients with cardiovascular disease. This review focuses on a platelet receptor, a transmembrane protein, the Multidrug Resistance Protein 4, MRP4, which contributes to platelet activation by extruding endogenous molecules responsible for their activation and…