CONCLUSIONS: Nocardia infection should be considered in the differential diagnoses for IPH patients receiving corticosteroid therapy, especially in patients with poor response to conventional empirical antibiotic therapy. Next-generation sequencing of bronchoalveolar lavage fluid may be used to quickly identify the Nocardia. Sulfonamides or linezolid are effective for pediatric pulmonary Nocardia infection.
CONCLUSIONS: Overall, the genome data allowed to place isolates into a phylogenetic context, and to identify different blaZ gene deletions associated to plasmid or transposons loss. Genomic analysis unveiled adaptation and evolution trends, namely among emerging MRSA lineages in the country, which deserves additional consideration in the design of future infection control protocols.
Mucocutaneous fungal infections are common and usually occur in the presence of certain risk factors. However, these infections can occur in patients with no known risk factors. This indicates the presence of an underlying genetic susceptibility to fungi reflecting an innate or adaptive immune deficiency. In this review, we highlight genetic factors that predispose to mucocutaneous fungal infections specially candidiasis and dermatophytosis.
CONCLUSION: RMs provided short-term improvements in end-expiratory lung volume and oxygenation. NSI with suction led to a reduced incidence of VAP; however, a definitive RCT is needed to test statistical differences. A RCT of study interventions is worthwhile and may be feasible with protocol modifications including the widening of participant eligibility.
Ten controlled studies evaluated antimicrobial use following implementation of the FilmArray meningitis and encephalitis panel versus usual care. Only one-half of studies identified significant reductions in antibiotic duration, with 8/10 reporting modest reductions for acyclovir. Coupling the FilmArray meningitis and encephalitis panel with interventions by antimicrobial stewardship programs may help enhance its clinical impact.
BACKGROUND: The Australian National Antimicrobial Resistance Strategy calls for a collaborative effort to change practices that have contributed to the development of drug-resistance and for implementation of new initiatives to reduce antibiotic use.
CONCLUSIONS: This study provides a baseline of antimicrobial use in relation to microbiological information in patients with the most common HAI. These results can serve to direct future effort of antimicrobial stewardship. Our work could be extended to a broader population, notably in Europe where similar surveys have been conducted.
CONCLUSION: Of 23 CZA-resistant CRKP strains (19.01%), ST11 being the most common at 56.52%, eleven NDM-1-positive (47.83%) and four NDM-5-positive (17.39%) strains were detected.
CONCLUSIONS: Results of this study indicate a high level of diversity among multidrug-resistant E. coli isolates from veal operations. The identification of multiple isolates encoding resistance to β-lactams, macrolides, and fluoroquinolones, as well as virulence factors responsible for human infections warrants more study on the ecology of antibiotic resistance on veal operations.