Currently browsing

julio 17, 2021

Multi-country cross-sectional study of colonization with multidrug-resistant organisms: protocol and methods for the Antibiotic Resistance in Communities and Hospitals (ARCH) studies

BACKGROUND: Antimicrobial resistance is a global health emergency. Persons colonized with multidrug-resistant organisms (MDROs) are at risk for developing subsequent multidrug-resistant infections, as colonization represents an important precursor to invasive infection. Despite reports documenting the worldwide dissemination of MDROs, fundamental questions remain regarding the burden of resistance, metrics to measure prevalence, and determinants of spread. We describe a multi-site colonization…

The Strategic Role of Healthcare Professionals in the Battle Against COVID-19: Do We Really Need Help from Community Pharmacists?

Wuhan, the capital of China’s Hubei province, was recognised in December 2019 as the centre of an outbreak of an unknown originator of pneumonia. Intense concentrations of illness spread throughout China and, ultimately, globally. Consequently, on 7th January, 2020, Chinese researchers identified a case of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in an affected person in Wuhan as the cause. Symptoms of SARS-CoV-2 vary from mild (fever, dry cough, difficulty in breathing, and…

Assessment of quarter billion primary care prescriptions from a nationwide antimicrobial stewardship program

We described the significance of systematic monitoring nationwide antimicrobial stewardship programs (ASPs) in primary care. All the prescriptions given by family physicians were recorded in Prescription Information System established by the Turkish Medicines and Medical Devices Agency of Ministry of Health. We calculated, for each prescription, «antibiotics amount» as number of boxes times number of items per box for medicines that belong to antiinfectives for systemic use (i.e., J01 block in…

Genomic analysis of a multidrug-resistant Brucella anthropi strain isolated from a 4-day old neonatal sepsis patient

CONCLUSION: B. anthropi SOA01 is a multi-drug resistant strain. Several AMR and VF genes were identified in the study genome, revealing the potential threat posed by this pathogen. The genome data generated in this study is likely to be useful in better understanding of its AMR mechanisms, pathogenic potential and its successful adaptation from its primary habitat of soil to the human system. Since, it is often misidentified as B. melitensis or B. suis genome characterization and detailed…

Evaluation of Optimal Treatment for Urinary Tract Infections in Outpatient Clinics at an Academic Medical Center: Opportunities for Antimicrobial Stewardship

Outpatient empiric urinary tract infection (UTI) prescribing is an area of interest for antimicrobial stewardship efforts. We conducted a retrospective chart review evaluating optimal antibiotic prescribing for UTIs in our internal medicine and urology clinics and found significant differences in prescribing patterns between provider type and UTI category. These data will inform our antimicrobial stewardship efforts in these clinics.