A case of pediatric acute lymphoblastic leukemia with invasive candidiasis: short review.

A case of pediatric acute lymphoblastic leukemia with invasive candidiasis: short review.

Indian J Hematol Blood Transfus. 2014 Sep;30(Suppl 1):101-4

Authors: Verma SP, Dubashi B, Narayanan P, Basu D, Dutta TK, Dhanraj KM

Abstract
Mortality rate associated with invasive fungal infections is very high. Early suspicion for fungal infections is important during intensive chemotherapy for acute leukemia. Empirical treatment with antifungals amphotericin B or caspofungin should be started if patient is not responding to broad spectrum antibiotics and if expected duration of neutropenia is prolonged. We are reporting a 3 years old girl child with diagnosis of pre-B acute lymphoblastic leukemia who developed invasive candidiasis with typical clinical and radiological findings during induction chemotherapy. Candida non-albicans was isolated and she was treated with amphotericin B followed by caspofungin. Patient deteriorated after initial response and succumbed to death. Species identification and sensitivity pattern of fungus can help in selecting appropriate antifungal drug.

PMID: 25332550 [PubMed]