A new polyphenolic isoprenylated acetophenone dimer from the stem bark of <em>Acronychia pedunculata</em> (L.) Miq

Nat Prod Res. 2021 Oct 11:1-8. doi: 10.1080/14786419.2021.1989680. Online ahead of print.


A new acetophenone dimer, 5'-prenylacrovestone (1), together with nineteen known compounds (2-20), were isolated from the stem bark of Acronychia pedunculata (L.) Miq. Their structures were identified by thorough analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. The isolated compounds were tested against the bacterial pathogens MRSA, B. cereus, S. aureus and E. coli. Compound 3 demonstrated exceptionally potent antibacterial activity against each of the four strains (MIC values of 1 µg/mL).

PMID:34632889 | DOI:10.1080/14786419.2021.1989680