A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition.

Related Articles

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition.

Cell Adh Migr. 2015 Aug 4;:1-8

Authors: Xu W, Yang Z, Lu N

Abstract
Tumor metastasis is not only a sign of disease severity but also a major factor causing treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms of tumor metastasis are critical for the development of treatments and for the improvement of survival. The epithelial-mesenchymal transition (EMT) is an orderly, polygenic biological process that plays an important role in tumor cell invasion, metastasis and chemoresistance. The complex, multi-step process of EMT involves multiple regulatory mechanisms. Specifically, the PI3K/Akt signaling pathway can affect the EMT in a variety of ways to influence tumor aggressiveness. A better understanding of the regulatory mechanisms related to the EMT can provide a theoretical basis for the early prediction of tumor progression as well as targeted therapy.

PMID: 26241004 [PubMed - as supplied by publisher]