A Selective Culture Medium for Screening Ceftazidime-Avibactam Resistance in Enterobacterales and Pseudomonas aeruginosa.

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A Selective Culture Medium for Screening Ceftazidime-Avibactam Resistance in Enterobacterales and Pseudomonas aeruginosa.

J Clin Microbiol. 2020 Jun 24;:

Authors: Sadek M, Poirel L, Tinguely C, Nordmann P

Abstract
The SuperCAZ/AVI medium was developed for screening ceftazidime-avibactam (CZA)-resistance among Gram-negative bacteria (Enterobacterales and Pseudomonas aeruginosa). It was evaluated using 50 CZA-susceptible and 42 CZA-resistant Gram-negative isolates. Its sensitivity and specificity of detection were 100%. By testing spiked stools, an excellent performance of the medium was also observed, with a lowest detection limit ranging from 101 to 102 CFU/ml. This screening medium provides the opportunity to detect CZA-resistant isolates regardless of their resistance mechanism.

PMID: 32580951 [PubMed - as supplied by publisher]