Abdominal candidiasis is a hidden reservoir of echinocandin resistance.
Antimicrob Agents Chemother. 2014 Dec;58(12):7601-5
Authors: Shields RK, Nguyen MH, Press EG, Clancy CJ
FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure (P = 0.01), breakthrough infections (P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida.
PMID: 25288081 [PubMed - indexed for MEDLINE]