Acquired resistance in fungi: how large is the problem.
Clin Microbiol Infect. 2019 Feb 27;:
Authors: Roilides E, Iosifidis E
To combat fungi that may harm the health of plants, animals and humans, a number of antifungal agents have been developed and used. Fungi may be primarily resistant to the antifungal drugs or may develop resistance after exposure to antifungals. Candida glabrata and other Candida spp. have developed mechanisms to acquire resistance to azoles and echinocandins. Aspergillus fumigatus has developed resistance to azoles by exposure to azoles in two different environments: the first is the respiratory tract of patients with chronic pulmonary aspergillosis. The second is in the nature due to exposure to agricultural azoles. The first article discusses the genetic and biochemical mechanisms that C. albicans, C. glabrata and the newly found multi-resistant Candida species, Candida auris, implement to develop resistance to azoles and echinocandins, and how they affect management of invasive candidiasis. The second article reviews recent insights in the well-established global problem of triazole resistance of A. fumigatus and how this challenges the patient management.
PMID: 30825677 [PubMed - as supplied by publisher]