Activating Antibacterial Effect of 4,6-diamino-2-pyrimidinethiol-modified Gold Nanoparticles by Reducing their Sizes.

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Activating Antibacterial Effect of 4,6-diamino-2-pyrimidinethiol-modified Gold Nanoparticles by Reducing their Sizes.

Angew Chem Int Ed Engl. 2020 Sep 04;:

Authors: Xie Y, Yang J, Zhang J, Zheng W, Jiang X

Abstract
Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)-modified DGNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (~14 nm in diameter) DGNPs (lDGNPs) and medium-sized (3-4 nm in diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram negative (G-) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) exhibit broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Together, our strategy, tuning antibacterial spectrum by modulating particle size, is insightful for exploring novel properties of the nanomaterials and their applications.

PMID: 32886827 [PubMed - as supplied by publisher]