Advances in Intra-abdominal Sepsis: What Is New?

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Advances in Intra-abdominal Sepsis: What Is New?

Curr Infect Dis Rep. 2015 Aug;17(8):497

Authors: Dietch ZC, Shah PM, Sawyer RG

Abstract
We have reviewed the literature regarding recent advances in the management of intra-abdominal sepsis, with a focus on antimicrobial agents, duration of therapy, and source control. Several important developments in these areas are discussed in this review. The introduction of a new antimicrobial agent-ceftolozane/tazobactam-marks the first novel agent for treating intra-abdominal infections in a number of years, and its indications for use and supporting evidence are reviewed here. In addition, we discuss recent evidence that clarifies the importance of early source control for intra-abdominal infection and new data that suggests that an abbreviated course of antimicrobial therapy for intra-abdominal infection is equally effective as prolonged therapy.

PMID: 26099701 [PubMed]