Anidulafungin and micafungin minimum inhibitory concentration breakpoints are superior to caspofungin for identifying FKS mutant Candida glabrata and echinocandin resistance.

Related Articles

Anidulafungin and micafungin minimum inhibitory concentration breakpoints are superior to caspofungin for identifying FKS mutant Candida glabrata and echinocandin resistance.

Antimicrob Agents Chemother. 2013 Sep 23;

Authors: Shields RK, Nguyen MH, Press EG, Updike CL, Clancy CJ

Abstract
By CLSI interpretive criteria, anidulafungin and micafungin MICs determined by various methods were sensitive (60-70%) and highly specific (94 - 100%) for identifying FKS mutations among 120 Candida glabrata isolates. Anidulafungin and micafungin breakpoints were more specific than CLSI's caspofungin breakpoint in identifying FKS mutant strains and patients with invasive candidiasis who were likely to fail echinocandin treatment (p≤0.0001 for both). Echinocandin MICs were most useful clinically when interpreted in the context of prior echinocandin exposure.

PMID: 24060873 [PubMed - as supplied by publisher]