Anti-fungal drug usage in hematologic patients during a 4-year period in an Asian university teaching hospital.
Intern Med J. 2012 Dec 24;
Authors: Chan TS, Hwang YY, Gill H, Cheung WW, Tse E, Leung AY, Chim CS, Lie AK, Kwong YL
Invasive fungal disease (IFD) is an important problem complicating the therapy of hematologic patients. We conducted a retrospective review of 275 hematologic patients who were prescribed anti-fungal drugs in a four-year period (2007-2010), of whom 130 (47%) had undergone hematopoietic stem cell transplantation. Antifungal prophylaxis with either fluconazole or itraconazole was given in 214 patients (78%). There were 414 prescriptions of anti-fungal drugs (including liposomal amphotericin B, voriconazole, caspofungin, micafungin, anidulafungin), of which 361 prescriptions were empirical. There were fourteen patients with proven IFD, eleven of whom had breakthrough infection while on itraconazole prophylaxis. Interestingly, seven of these cases were due to infection by itraconazole-sensitive candida. These results provide important epidemiologic data necessary for the formulation of strategies for prevention and treatment of IFD in Asian patients.
PMID: 23279203 [PubMed - as supplied by publisher]