Antibiofilm activity of carboxymethyl chitosan on the biofilms of non-Candida albicans Candida species.

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Antibiofilm activity of carboxymethyl chitosan on the biofilms of non-Candida albicans Candida species.

Carbohydr Polym. 2016 Sep 20;149:77-82

Authors: Tan Y, Leonhard M, Moser D, Schneider-Stickler B

Abstract
Although most cases of candidiasis have been attributed to Candida albicans, non-C. albicans Candida species have been isolated in increasing numbers in patients. In this study, we determined the inhibition of carboxymethyl chitosan (CM-chitosan) on single and mixed species biofilm of non-albicans Candida species, including Candida tropicalis, Candida parapsilosis, Candida krusei and Candida glabrata. Biofilm by all tested species in microtiter plates were inhibited nearly 70%. CM-chitosan inhibited mixed species biofilm in microtiter plates and also on medical materials surfaces. To investigate the mechanism, the effect of CM-chitosan on cell viability and biofilm growth was employed. CM-chitosan inhibited Candida planktonic growth as well as adhesion. Further biofilm formation was inhibited with CM-chitosan added at 90min, 12h or 24h after biofilm initiation. CM-chitosan was not only able to inhibit the metabolic activity of Candida cells, but was also active upon the establishment and the development of biofilms.

PMID: 27261732 [PubMed - in process]