Antibiotic Stewardship for Drug resistant Tuberculosis.
Expert Opin Pharmacother. 2016 Aug 23;
Authors: Padayatchi N, Mahomed S, Loveday M, Naidoo K
Increasing rates of anti-TB drug resistance coupled with the narrow pipe-line of anti-TB drug development, highlights the need for judicious use of new and old anti-TB drugs. New drugs, such as bedaquiline and delamanid have become available for the treatment of resistant TB. The introduction of repurposed drugs, such as linezolid, is also seen as an attractive addition to drug resistant TB regimens. To ensure sustained efficacy and mitigate inappropriate use of these new drugs it is essential to apply the concepts of antibiotic stewardship to TB therapy. The aim of stewardship is to protect both old and new drugs from incorrect use and thereby prolong its usefulness. To achieve the goals of stewardship, the following strategies should be instituted: a stewardship team to lead and develop institutional programs; ongoing education for health care workers to rationalise drug use, "formulary restriction", and pharmacovigilance and treatment adherence strategies.
PMID: 27550243 [PubMed - as supplied by publisher]