Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus.
Asian Pac J Trop Med. 2015 Jul;8(7):538-42
Authors: Choi JG, Choi JY, Mun SH, Kang OH, Bharaj P, Shin DW, Chong MS, Kwon DY
OBJECTIVE: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test.
METHODS: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2000 μg/mL and 125 to 1000 μg/mL against MRSA, respectively.
RESULTS: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h.
CONCLUSIONS: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.
PMID: 26276284 [PubMed]