Antimicrobial photodynamic therapy for oral candidiasis not responsive to micafungin in a patient undergoing hematopoietic cell transplantation

Photodiagnosis Photodyn Ther. 2021 Apr 15:102296. doi: 10.1016/j.pdpdt.2021.102296. Online ahead of print.


In hematopoietic cell transplants (HCT) patients, opportunistic fungal infections - especially candidiasis - are typical and, due to the immunosuppressed condition, severe and fatal clinical conditions may occur. Many antifungal agents are used for treating candidiasis; however, there are non-responsive, drug-resistant cases in which alternative antimicrobial therapies are strongly needed. The present study aimed to report a clinical case in which antimicrobial photodynamic therapy (aPDT) was used for extensive oral pseudomembranous candidiasis not responsive to micafungin in a patient undergoing HCT. Thus, 0.01% methylene blue solution was applied for 3 minutes onto the infected area, followed by 660-nm laser irradiation. Within 72 hours, there was neither a symptom nor a sign of the fungal infection. According to the current case report, aPDT seems to be highly effective for HCT patients presenting oral candidiasis not responsive to micafungin; however, further studies are necessary.

PMID:33866015 | DOI:10.1016/j.pdpdt.2021.102296