Assessment of hypersensitivity reactions in patients receiving carbapenem antibiotics who report a history of penicillin allergy.

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Assessment of hypersensitivity reactions in patients receiving carbapenem antibiotics who report a history of penicillin allergy.

J Chemother. 2014 Jun;26(3):150-3

Authors: Wall GC, Nayima VA, Neumeister KM

Abstract
BACKGROUND: The use of carbapenem antibacterials in patients with a claimed history of penicillin allergy is somewhat controversial. This study aimed to examine the rates of presumed hypersensitivity reactions in a large cohort of patients receiving carbapenem antibiotics.
METHODS: A retrospective chart review was performed on all adult patients who received a carbapenem in a teaching hospital from June 2011 to June 2012. Information procured included listed penicillin allergy and reaction if known, type of carbapenem received, and any allergic reaction during that admission.
RESULTS: Nine-hundred and fifty eight patients who received a carbapenem antimicrobial were reviewed. Five patients developed a presumed reaction to carbapenem: one in the penicillin allergy group and four in the non-allergic group. There were no statistical or numerical differences in rates of reaction between the two groups.
CONCLUSION: Patients with a claimed history of penicillin allergy were not more likely to develop a presumed hypersensitivity reaction to a carbapenem compared to those who did not claim such an allergy.

PMID: 24090971 [PubMed - indexed for MEDLINE]