Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from United States and European Medical Centers (2016-2018).
Antimicrob Agents Chemother. 2020 Feb 03;:
Authors: Carvalhaes CG, Sader HS, Flamm RK, Streit JM, Mendes RE
High-level aminoglycoside resistance was noted in 30.0% of Enterococcus faecalis and 25.2% of Enterococcus faecium. Only 3.3% and 2.1% of E. faecalis showed elevated daptomycin MIC (≥2 mg/liter) and vancomycin resistance, respectively. In contrast, 37.4-40.3% of E. faecium exhibited these phenotypes. Tedizolid inhibited 98.9-100.0% of enterococci causing serious invasive infections, including resistant subsets. Oxazolidinone resistance was mainly driven by G2576T; however, optrA and poxtA genes were also detected, including poxtA in the USA and Turkey.
PMID: 32015026 [PubMed - as supplied by publisher]