Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.
ERJ Open Res. 2019 Apr;5(2):
Authors: Metcalfe J, Bacchetti P, Gerona R, Esmail A, Dheda K, Gandhi M
Therapeutic drug monitoring for drug-resistant tuberculosis (TB) is likely to improve treatment outcomes. While assessments of plasma drug levels can explain pharmacokinetic variability among trial participants, these measures require phlebotomy and a cold chain, and are generally not repeated frequently enough to characterise drug exposure over time. Using a novel multi-analyte assay, we found evidence that higher anti-TB drug concentrations in hair, a non-biohazardous and noninvasively collected biomatrix, predict extensively-drug resistant-TB clinical outcomes in a high-burden setting.
PMID: 31041318 [PubMed]