Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy.

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy.

J Clin Immunol. 2015 Jul 5;

Authors: Kisand K, Peterson P

Abstract
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene. This review focuses on the clinical and immunological features of APECED, summarizes the current knowledge on the function of AIRE and discusses the importance of autoantibodies in disease diagnosis and prognosis. Additionally, we review the outcome of recent immunomodulatory treatments in APECED patients.

PMID: 26141571 [PubMed - as supplied by publisher]