Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition.

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Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition.

ACS Nano. 2019 Nov 15;:

Authors: Lin A, Liu Y, Zhu X, Chen X, Liu J, Zhou Y, Qin X, Liu J

Abstract
Multidrug-resistant (MDR) bacterial infections are severe threat to public health owing to their high fatalness. Noticeably, the premature degradation and undeveloped imaging ability of antibiotics still remain challenging. Herein, a selenium nanosystem in responsive of bacteria-infected micro-environment is proposed as an antibiotic substitute to detect and inhibit methicillin-resistant Staphylococcus aureus (MRSA) with a combined strategy. Using natural red blood cell membrane (RBCM) and bacteria-responsive gelatin nanoparticles (G NPs), the Ru-Se@G NPs-RBCM nanosystem was constructed for effective delivery of Ru complex modified selenium nanoparticles (Ru-Se NPs). Taking advantage of natural RBCM, the immune system clearance was reduced and exotoxins was neutralized efficiently. G NPs could be degraded by gelatinase in pathogen-infected area in situ, therefore Ru-SeNPs were released to destroy the bacteria cells. Ru-SeNPs with intense fluorescence imaging capability could accurately monitor the infection treatment process subsequently. Moreover, excellent in vivo bacteria elimination and facilitated wound healing process were confirmed by two kinds of MRSA-infected mice models. Overall, the above advantages proved the prepared nanosystem a promising antibiotic alternative to combat the ever-threatening multidrug-resistant bacteria.

PMID: 31730327 [PubMed - as supplied by publisher]