Burden of Fungal Disease - Ireland.
J Med Microbiol. 2015 Jan 16;
Authors: Dorgan E, Denning DW, McMullan R
To estimate the burden of fungal disease on the island of Ireland, as part of a coordinated project estimating its global burden.Published epidemiology data describing fungal infection in Ireland were identified. Population and underlying disease data were collected for 2010 and a structured set of assumptions were applied to estimate burden of fungal disease based on immunosuppression, chronic disease, and other demographic information indicating predisposition to fungal infection. From Ireland's population of 6.4million, we estimate 117,000 patients develop significant fungal disease each year. By far the most common fungal disease is recurrent Candida vaginitis, with an estimated 95,000 episodes annually (3000 per 100000 women). Other fungal diseases which may be less well recognised are severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary asergillosis (ABPA), with estimated episodes per year of 11700 and 9000, respectively (182 and 140 per 100000 population, respectively). The model also estimates 450 episodes of invasive aspergillosis, 200 of chronic pulmonary aspergillosis, 600 of oesophageal candidiasis, and 450 of candidaemia per year (7, 3, 9, and 6 episodes per 100000population, respectively). This is the first known attempt to estimate the burden of fungal disease in our population and provides a basis for estimating its impact on human health and resource use.
PMID: 25596121 [PubMed - as supplied by publisher]