Can chitotriosidase be a surrogate marker for invasive fungal disease?

Can chitotriosidase be a surrogate marker for invasive fungal disease?

J Mycol Med. 2012 Sep;22(3):256-60

Authors: Coskun O, Ozturk M, Erdem H, Gumral R, Yaman H, Karakas A, Kilic S, Eyigun CP

Abstract
BACKGROUND: Chitotriosidase (CHT) enzyme has been known to be secreted from the activated macrophages. We infer with these data that CHT activity is an indicator for the defence.
METHODS: In this study, we evaluated CHT levels in both neutropenic and non neutropenic patients. CHT enzyme activity was measured and compared to each other groups.
RESULTS: Chitotriosidase levels were found to be significantly higher in neutropenic patients with candidemia.
CONCLUSION: In the comparison between neutropenic and non neutropenic patients, there was a significant difference for CHT levels. The use of this enzyme as a surrogate marker for candidemias were evaluated in neutropenic and non neutropenic patients.

PMID: 23518084 [PubMed - in process]

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