Can chitotriosidase be a surrogate marker for invasive fungal disease?
J Mycol Med. 2012 Sep;22(3):256-60
Authors: Coskun O, Ozturk M, Erdem H, Gumral R, Yaman H, Karakas A, Kilic S, Eyigun CP
BACKGROUND: Chitotriosidase (CHT) enzyme has been known to be secreted from the activated macrophages. We infer with these data that CHT activity is an indicator for the defence.
METHODS: In this study, we evaluated CHT levels in both neutropenic and non neutropenic patients. CHT enzyme activity was measured and compared to each other groups.
RESULTS: Chitotriosidase levels were found to be significantly higher in neutropenic patients with candidemia.
CONCLUSION: In the comparison between neutropenic and non neutropenic patients, there was a significant difference for CHT levels. The use of this enzyme as a surrogate marker for candidemias were evaluated in neutropenic and non neutropenic patients.
PMID: 23518084 [PubMed - in process]