Candida albicans and Candida parapsilosis induce different T-cell responses in human PBMCs.
J Infect Dis. 2013 May 9;
Authors: Tóth A, Csonka K, Jacobs C, Vágvölgyi C, Nosanchuk JD, Netea MG, Gácser A
Candida parapsilosis is the third most frequent cause of candidemia. Despite its clinical importance, little is known about the human immunological response to C. parapsilosis. In this study, we compared the cytokine responses evoked by C. albicans and C. parapsilosis. C. parapsilosis-stimulated human peripheral blood mononuclear cells (PBMCs) produced similar quantities of TNFα and IL-6, and slightly lower amounts of IL-1β, compared to C. albicans-stimulated cells. PBMCs stimulated with C. parapsilosis displayed a skewed T-helper response, producing more IL-10 and less IFNγ compared to cells stimulated with C. albicans. Notably, C. parapsilosis induced much less IL-17 and IL-22 production compared to C. albicans. Inhibition of the three classical MAP kinases (p38, ERK, JNK) revealed kinase-dependent differences in reductions in cytokine production by the two Candida species. Decreased cytokine production after inhibition of Dectin-1 revealed that this receptor plays a major role in the recognition of both C. albicans and C. parapsilosis. These data contribute to the better understanding of the immune response triggered by Candida parapsilosis, a first step for future design of immunotherapeutic strategies in these infections.
PMID: 23661798 [PubMed - as supplied by publisher]