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Chem Biodivers

Chemical Characteristics, Antimicrobial and Cytotoxic Activities of the Essential Oil of Egyptian Cinnamomum glanduliferum Bark.

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Chemical Characteristics, Antimicrobial and Cytotoxic Activities of the Essential Oil of Egyptian Cinnamomum glanduliferum Bark.

Chem Biodivers. 2017 Feb 11;:

Authors: Taha AS, Eldahshan OA

Abstract
The essential oil isolated from the bark of Cinnamomum glanduliferum (Wall) Meissn that grown in Egypt was screened for the first time. The chemical composition was analyzed by GC and GC/Mass. The antimicrobial activity of the oil was assessed using agar-well diffusion method toward representatives for each of Gram-positive bacteria, Gram-negative bacteria, and fungi. The cytotoxic activity was checked using three human cancer cell lines. Twenty seven compounds were identified, representing 99.07% of the total detected components. The major constituents were eucalyptol (65.87%), terpinen-4-ol (7.57%), α-terpineol (7.39%). The essential oil possessed strong antimicrobial activities against Escherichia coli, as the activity index (AI) equal to one and MIC is 0.49 μg/mL. Good antimicrobial activities were against methicillin-resistant Staphylococcus aureus, Geotrichum candidum, Pseudomonas aeruginosa, Bacillus subtilis, Helicobacter pylori, Aspergillus fumigatus (MIC: 7.81, 1.95, 7.81, 0.98, 31.25, and 32.5 μg/mL respectively). A considerable activity was observed against Staphylococcus aureus and Mycobacterium tuberculosis (MIC; 32.5 and 31.25 μg/mL). It was toxic to colon (HCT-116), liver (HepG2), and breast (MCF-7) carcinoma cell lines at IC50 9.1, 42.4, and 57.3 μg/mL. These results revealed Egyptian Cinnamomum glanduliferum bark oil possess antimicrobial and cytotoxic activities mainly due to eucalyptol and other major compounds. This article is protected by copyright. All rights reserved.

PMID: 28190283 [PubMed – as supplied by publisher]

Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes.

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Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes.

Chem Biodivers. 2015 Aug;12(8):1214-21

Authors: Rédei D, Boros K, Forgo P, Molnár J, Kele Z, Pálinkó I, Pinke G, Hohmann J

Abstract
Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel (1, 2) and one known (3) jatrophane diterpenes. Their structures were established by extensive 1D- and 2D-NMR spectroscopy and HR-ESI-MS. The isolated compounds were evaluated for multidrug resistance (MDR) reversing activity on human MDR gene-transfected L5178 mouse lymphoma cells; and all three compounds were found to modulate the intracellular drug accumulation.

PMID: 26265573 [PubMed – in process]

Sesquiterpenoids with Anti-MDR Staphylococcus aureus Activities from Ferula ferulioides.

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Sesquiterpenoids with Anti-MDR Staphylococcus aureus Activities from Ferula ferulioides.

Chem Biodivers. 2015 Apr;12(4):599-614

Authors: Liu T, Wang S, Xu L, Fu W, Gibbons S, Mu Q

Abstract
Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.

PMID: 25879504 [PubMed – in process]