Chemical Characteristics, Antimicrobial and Cytotoxic Activities of the Essential Oil of Egyptian Cinnamomum glanduliferum Bark.
Chem Biodivers. 2017 Feb 11;:
Authors: Taha AS, Eldahshan OA
The essential oil isolated from the bark of Cinnamomum glanduliferum (Wall) Meissn that grown in Egypt was screened for the first time. The chemical composition was analyzed by GC and GC/Mass. The antimicrobial activity of the oil was assessed using agar-well diffusion method toward representatives for each of Gram-positive bacteria, Gram-negative bacteria, and fungi. The cytotoxic activity was checked using three human cancer cell lines. Twenty seven compounds were identified, representing 99.07% of the total detected components. The major constituents were eucalyptol (65.87%), terpinen-4-ol (7.57%), α-terpineol (7.39%). The essential oil possessed strong antimicrobial activities against Escherichia coli, as the activity index (AI) equal to one and MIC is 0.49 μg/mL. Good antimicrobial activities were against methicillin-resistant Staphylococcus aureus, Geotrichum candidum, Pseudomonas aeruginosa, Bacillus subtilis, Helicobacter pylori, Aspergillus fumigatus (MIC: 7.81, 1.95, 7.81, 0.98, 31.25, and 32.5 μg/mL respectively). A considerable activity was observed against Staphylococcus aureus and Mycobacterium tuberculosis (MIC; 32.5 and 31.25 μg/mL). It was toxic to colon (HCT-116), liver (HepG2), and breast (MCF-7) carcinoma cell lines at IC50 9.1, 42.4, and 57.3 μg/mL. These results revealed Egyptian Cinnamomum glanduliferum bark oil possess antimicrobial and cytotoxic activities mainly due to eucalyptol and other major compounds. This article is protected by copyright. All rights reserved.
PMID: 28190283 [PubMed – as supplied by publisher]