Currently browsing category

Infecciones en adultos

Iatrogenic Cushing’s syndrome induced by posaconazole.

Related Articles
Iatrogenic Cushing’s syndrome induced by posaconazole.
Antimicrob Agents Chemother. 2013 Aug 26;
Authors: Pilmis B, Coignard-Biehler H, Jullien V, Hermine O, Touraine P, Lecuit M, Lortholary O
Abstrac…

No difference between posaconazole and fluconazole antifungal prophylaxis and mycological diagnostics except costs in patients undergoing AML chemotherapy: a 1-year «real-life» evaluation.

Related Articles

No difference between posaconazole and fluconazole antifungal prophylaxis and mycological diagnostics except costs in patients undergoing AML chemotherapy: a 1-year «real-life» evaluation.

Ann Hematol. 2013 Aug 15;

Authors: Bertz H, Drognitz K, Lübbert M

PMID: 23949313 [PubMed – as supplied by publisher]

In vitro susceptibility of Conidiobolus lamprauges recovered from sheep to antifungal agents.

Related Articles

In vitro susceptibility of Conidiobolus lamprauges recovered from sheep to antifungal agents.

Vet Microbiol. 2013 Aug 2;

Authors: Tondolo JS, Loreto ES, Dutra V, Nakazato L, Paula DA, Zanette RA, Alves SH, Santurio JM

Abstract
Data regarding the susceptibility of Conidiobolus lamprauges is limited and there is no consensus about the optimal treatment for infections caused by Conidiobolus spp. In this context, the objective of this study was to evaluate the in vitro susceptibility of six C. lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. Terbinafine was the most active (MIC range <0.06-0.5μg/mL). Resistance or reduced susceptibility was observed for amphotericin B and azole and echinocandin antifungals. Additional studies are necessary to determine the therapeutic potential of terbinafine as monotherapy or in combination therapy with other antifungals.

PMID: 23958402 [PubMed – as supplied by publisher]

Outbreak of ertapenem-resistant Enterobacter cloacae urinary tract infections due to a contaminated ureteroscope.

Related Articles

Outbreak of ertapenem-resistant Enterobacter cloacae urinary tract infections due to a contaminated ureteroscope.

J Hosp Infect. 2013 Aug 15;

Authors: Chang CL, Su LH, Lu CM, Tai FT, Huang YC, Chang KK

Abstract
BACKGROUND: Outbreaks of urinary tract infections (UTIs) due to contaminated ureteroscopes have been rarely reported.
AIM: To report such an outbreak at a regional teaching hospital in southern Taiwan.
METHODS: From October to December 2010, ertapenem-resistant Enterobacter cloacae were identified from urine cultures of 15 patients who had undergone ureteroscopy prior to the infection. Three batches of surveillance cultures were obtained from the environmental objects and healthcare workers related to the procedures. Pulsed-field gel electrophoresis (PFGE) was used for bacterial typing. Antimicrobial susceptibility was assessed by disc diffusion and E-test methods. Polymerase chain reaction and sequencing were used to analyse β-lactamase genes.
FINDINGS: A total of 70 specimens were obtained during the first surveillance operation. One ertapenem-resistant E. cloacae was isolated from a ureteroscope. Although the disinfection protocols for ureteroscopes were revised and implemented, seven additional UTI cases were identified thereafter. The pathogen was identified from two subsequent surveillance cultures and was not eliminated until ethylene oxide sterilization was added to the disinfection protocol. PFGE revealed that all 15 isolates from the patients and the three isolates from the ureteroscope shared a common pattern with minor variance. Most isolates were resistant to gentamicin, levofloxacin, ceftriaxone, ceftazidime, and ertapenem. All isolates were susceptible to amikacin, imipenem, and meropenem. SHV-12 and IMP-8 genes were simultaneously identified in 16 of the 18 isolates.
CONCLUSION: The outbreak of ertapenem-resistant E. cloacae was caused by a contaminated ureteroscope and was terminated by the implementation of a revised disinfection protocol for ureteroscopes.

PMID: 23954065 [PubMed – as supplied by publisher]

Pharmacological characteristics of ertapenem.

Related Articles

[Pharmacological characteristics of ertapenem.]

Klin Mikrobiol Infekc Lek. 2013 Mar;19(1):8-10

Authors: Urbánek K, Suchánková H

Abstract
Ertapenem is a broad-spectrum bactericidal carbapenem antibiotic. It differs from the other substances of this group by the absence of action against Gram-negative non-fermenting bacilli and by a long elimination half-life, which allows once-daily administration. It is administered once daily in a dose of 1 gram intravenously. Ertapenem is generally well-tolerated, with the most common side effects being diarrhea and phlebitis at the injection site. It is used for the treatment of community-acquired pneumonia, intra-abdominal and gynecological infections, and skin and soft tissue infections, including diabetic foot.

PMID: 23945830 [PubMed – as supplied by publisher]