Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series

J Clin Pharm Ther. 2020 Nov 28. doi: 10.1111/jcpt.13317. Online ahead of print.


WHAT IS KNOWN AND OBJECTIVE: Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration.

CASE DESCRIPTION: Thirteen of 14 isavuconazole concentrations were >1 mg/dl (median 1.6 mg/dl) among those receiving enteral tube administration, which was comparable to intravenous (median 1.9 mg/dl). Higher concentrations were observed during oral administration (median 3 mg/dl).

WHAT IS NEW AND CONCLUSION: Administration of isavuconazole via tube resulted in concentrations comparable to FDA-approved routes of administration. This route may be feasible and appropriate for select patients.

PMID:33247433 | DOI:10.1111/jcpt.13317