Chronic high-level multidrug-resistant Campylobacter coli enterocolitis in an agammaglobulinemia patient: gentamicin efficacy.

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Chronic high-level multidrug-resistant Campylobacter coli enterocolitis in an agammaglobulinemia patient: gentamicin efficacy.

Med Mal Infect. 2020 Apr 27;:

Authors: Dan M, Parizade M

Abstract
BACKGROUND: Campylobacter is the most common cause of infectious diarrhea in agammaglobulinemia patients. These infections can be severe, prolonged, and recurrent in such patients.
PATIENT AND METHODS: We report a 29-year-old male patient with X-linked agammaglobulinemia with Campylobacter coli enterocolitis that persisted for nine months despite multiple 10- to 14-day courses of oral ciprofloxacin and azithromycin.
RESULTS: The isolate was highly resistant to ciprofloxacin, erythromycin, tetracycline, and fosfomycin. The patient failed to respond to intravenous ertapenem, 1.0 gram/day for two weeks, to which the pathogen was susceptible. He was finally cured with oral gentamicin, 80 mg four times daily, and stool cultures remained negative during the seven-month follow-up.
CONCLUSION: Oral aminoglycoside might be the most appropriate choice for eradication of persistent Campylobacter in the intestinal tract for macrolide- and fluoroquinolone-resistant isolate in agammaglobulinemia patients with chronic diarrhea or relapsing systemic infections.

PMID: 32353415 [PubMed - as supplied by publisher]