Clearance of Persistent Staphylococcus aureus Bacteremia in a Preterm Neonate With the Use of Combination Cefazolin and Ertapenem.

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Clearance of Persistent Staphylococcus aureus Bacteremia in a Preterm Neonate With the Use of Combination Cefazolin and Ertapenem.

J Pediatr Pharmacol Ther. 2020;25(6):547-551

Authors: Akers SM, Kinney K, Butcher MI, Moïse A

Abstract
Late-onset sepsis caused by Staphylococcus aureus is a serious and relatively common complication encountered by preterm neonates in NICUs. Typical treatment regimens for invasive methicillin-sensitive Staphylococcus aureus (MSSA) include semisynthetic beta lactam antibiotics, such as nafcillin. This report describes the first use of a combination of cefazolin and ertapenem to successfully treat persistent MSSA bacteremia in a preterm neonate who failed traditional first-line therapy.

PMID: 32839659 [PubMed]