Clinical characteristics of bacteraemia caused by extended-spectrum β-lactamase-producing Enterobacteriaceae… [Clin Microbiol Infect. 2011] – PubMed – NCBI

Clin Microbiol Infect. 2011 Aug 25. doi: 10.1111/j.1469-0691.2011.03658.x. [Epub ahead of print]

Clinical characteristics of bacteraemia caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in the era of CTX-M-type and KPC-type β-lactamases.


Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA  University of Queensland, UQ Centre for Clinical Research and Royal Brisbane and Women’s Hospital, Brisbane, Queensland  Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia  Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA  Divisions of Infectious Diseases and Epidemiology  Department of Pathology, St Luke’s-Roosevelt Hospital Center, New York, NY, USA.


Clin Microbiol Infect ABSTRACT: A multicentre, case-control study was conducted to assess risk factors and patient outcomes of bacteraemia caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) and Klebsiella pneumoniae carbapenemases (KPCs). One hundred and five and 20 patients with bacteraemia caused by ESBL-producing and KPC-producing organisms were matched to controls who had bacteraemia caused by non-ESBL/KPC-producing organisms, respectively. Independent risk factors for ESBL production included admission from a nursing home (OR 4.64; 95% CI 2.64-8.16), chronic renal failure (OR 2.09; 95% CI 1.11-3.92), the presence of a gastrostomy tube (OR 3.36; 95% CI 1.38-8.18), length of hospital stay before infection (OR 1.02; 95% CI 1.01-1.03), transplant receipt (OR 2.48; 95% CI 1.24-4.95), and receipt of antibiotics with Gram-negative activity in the preceding 30 days (OR 1.76; 95% CI 1.00-3.08). Twenty-eight-day crude mortality rates for patients infected with ESBL-producing or KPC-producing organisms and controls were 29.1% (34/117) and 19.5% (53/272), respectively (OR 1.70; 95% CI 1.04-2.80). On multivariate analysis, inadequate empirical therapy (OR 2.26; 95% CI 1.18-4.34), onset of bacteraemia while in the intensive-care unit (OR 2.74; 95% CI 1.47-5.11), Apache II score (OR 1.17; 95% CI 1.12-1.23) and malignancy (OR 2.66; 95% CI 1.31-5.41) were independent risk factors for mortality. CTX-M was the most common ESBL type in Escherichia coli, whereas SHV predominated in Klebsiella spp. and Enterobacter spp.

© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

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