Clinical significance of filamentous basidiomycetes, illustrated by the novel opportunist Ceriporia lacerata isolated from the human respiratory tract.

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Clinical significance of filamentous basidiomycetes, illustrated by the novel opportunist Ceriporia lacerata isolated from the human respiratory tract.

J Clin Microbiol. 2012 Dec 12;

Authors: Chowdhary A, Agarwal K, Kathuria S, Singh PK, Roy P, Gaur SN, de Hoog GS, Meis JF

Abstract
The filamentous basidiomycete, Ceriporia lacerata, an agent of white-rot of wood, has never been reported in human disease and its clinical significance is not yet known. We describe 4 patients with respiratory diseases where C. lacerata was implicated in a wide spectrum of clinical manifestations ranging from saprobic colonization to fungal pneumonia. The isolates did not show the morphological characteristics that facilitate recognition of filamentous basidiomycetes such as presence of clamp connections, spicules along hyphae or fruiting bodies. The identity of the mold was confirmed by sequencing ITS 1/4 and D1/D2 regions of the rRNA gene. All of the isolates exhibited lowest MIC of posaconazole and isavuconazole (MIC range 0.06-0.125 μg/ml) followed by itraconazole (MIC range, 0.06-0.5 μg/ml), voriconazole (MIC range, 0.125-0.5 μg/ml) and amphotericin B (MIC range 0.25-1 μg/ml). The infections reported here occurred in patients with pre-existing lung damage induced by tuberculosis or chronic obstructive pulmonary disease. Chronic, sometimes fatal infections by the ascomycete, Aspergillus fumigatus and the basidiomycete, Schizophyllum commune is well-established in the presence of an anatomical pulmonary defect or in the background of immunodeficiency. It is postulated that C. lacerata, a novel opportunist basidiomycete, may be involved in similar pathologic processes.

PMID: 23241374 [PubMed - as supplied by publisher]