Comparative Efficacy of Tedizolid Phosphate, Linezolid and Vancomycin in a Murine Subcutaneous (subQ) Catheter-Related Biofilm Infection Model due to Methicillin-Susceptible and -Resistant Staphylococcus aureus.

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Comparative Efficacy of Tedizolid Phosphate, Linezolid and Vancomycin in a Murine Subcutaneous (subQ) Catheter-Related Biofilm Infection Model due to Methicillin-Susceptible and -Resistant Staphylococcus aureus.

Antimicrob Agents Chemother. 2016 Jun 13;

Authors: Bayer AS, Abdelhady W, Li L, Gonzales R, Xiong YQ

Abstract
Tedizolid, a novel oxazolidinone, exhibits bacteriostatic activity through inhibition of protein synthesis. The efficacy of tedizolid, linezolid and vancomycin was compared in a murine catheter-related biofilm infection caused by bioluminescently engineered methicillin-susceptible and -resistant S. aureus (MSSA and MRSA) strains. We observed a significantly improved efficacy in decreased S. aureus densities and bioluminescent signals (BLS) in the tedizolid treated group vs linezolid and vancomycin groups in the model caused by the MSSA and MRSA strains.

PMID: 27297485 [PubMed - as supplied by publisher]