Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe

Open Forum Infect Dis. 2021 Jan 4;8(2):ofaa653. doi: 10.1093/ofid/ofaa653. eCollection 2021 Feb.


We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB). Of 322 MDR-TB patients (19.4% HCV), 30 were treated concomitantly (23.3% human immunodeficiency virus-positive). Overall, 76.7% achieved HCV treatment success (95.8% among tested). One patient (3.3%) experienced a serious adverse event.

PMID:33634203 | PMC:PMC7896641 | DOI:10.1093/ofid/ofaa653